Endocrine Abstracts

Introduction: Brain metastases of thyroid carcinomas are rare (0.1–5%) according to the literature data. They generally occur in a context of metastatic spread which has a serious impact on survival. We report two cases and will review the literature data.

Observations: Case 1: 57-year-old patient monitoring for papillary thyroid carcinoma in its solid form trabecular classified T4N0M1with lung metastases. Following a neurological symptoms of tonic-clonic type of the left arm cerebro-spinal MRI revealed a 20 mm right parietal lesion and cerebellar lesion 4 mm. The rest of the staging finds multiple hepatic nodules probably metastatic. Up-take scan after radioiodine therapy was positive in cervical, brain and lung. thyroglobulin rates are increased to 3050 ng/ml.

Case 2: 11-year-old patient with a vesicular thyroid carcinoma with multiple secondary metastases: brain, lung, bone, pancreas, liver. The histological study of parietal localization confirmed his thyroid origin. Up-take scan after radioiodine therapy was positive especially in brain. thyroglobulin levels are increased to 8000 ng/ml.

Conclusion: Patients with thyroid carcinoma metastatic to the brain appear to have a relatively short survival time compared with other patients with thyroid carcinoma, although this survival time is significantly longer than that noted with other solid tumour metastases to the brain. Early detection is important and specific treatment (radioiodine therapy) and standard treatments (surgery, Whole Brain Radiation Therapy) can improve their prognosis.