ECE2015 Eposter Presentations Pituitary: clinical (121 abstracts)
Long-term recurrence in nonfunctional pituitary adenomas after surgery
Maria Galiana Rodriguez Caballero , Nuria Valdés Gallego , Jessica Ares Blanco , Cecilia Sánchez Ragnarsson , Laura Cacho , Joaquín Pertierra de la Uz , Antonio Rabal Artal , Lorena Suárez Gutierrez , Elias Delgado , Pablo Martinez Camblor , Ceferino Faedo & Edelmiro Menéndez Torre
Hospital Universitario Central de Asturias, Oviedo, Spain.
Object: Nonfunctioning pituitary adenomas can experiment recurrence and/or progression (R/P) several years after surgery in about 15–50% of patients. There is few evidence about risk factors that could predict R/P. The aim of this study is to identify them and describe our experience through a long term of follow-up in pituitary macroadenomas.
Methods: Retrospective cohort analysis of 64 patients who underwent surgery between 1990 and 2013. The main outcome was to evaluate prevalence of R/P during the follow-up, based on imaging criteria and identify some risk factors for R/P.
Results: Over a median follow-up of 10.12 years, there was 46% of R/P after surgery at a median time of 4.6 years, the cumulative risk of being free of R/P was 62% by 5 years and decrease to 45% by 15 years after surgery. Multivariate cox proportional hazard regression analysis identified the following risk factors as associated with increased risk of recurrence: radiotherapy after surgery (hazard ratio 2.90, 95% CI 1.15–7.46, P=0.023) and the tumour size at diagnosis (hazard ratio 1.05 CI 1.009–1.10, P=0.019).
Conclusions: Patients with NFPA need long-term follow-up because they have a high risk of R/P over time. Radiotherapy after surgery decreases the risk of recurrence or progression specially after five years. The tumour size at diagnosis is an independently risk of R/P.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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