ECE2015 Eposter Presentations Adrenal cortex (94 abstracts)
Prevalence of Cushing's syndrome at overweight and obese patients
Mehtap Navdar Basaran 1 , Berçem Ayçiçek Doğan 1 , Eda Demir Önal 1 , Ersen Karakılıç 1 , Dilek Berker 1 & Serdar Güler 1,
1Numune Education and Training Hospital Endocrinology Department, Ankara, Turkey; 2Hitit University Medical Faculty Endocrinology Department, Çorum, Turkey.
Background: In the presence of specific symptoms and signs, Cushing’s syndrome (CS) may be easily recognised. On the other hand, in overweight and obese patients without typical features of CS, diagnosis may be omitted. Our aim was to evaluate the prevalence of CS among overweight and obese patients.
Methods: We enrolled 264 overweight and obese patients who has not overt CS clinical features between January 2012 and December 2014 at Ankara Numune Education and Training Hospital. All patients were screened via overnight 1 mg dexamethasone suppression test (DST). Patients who had positive screening test has undergone other diagnostic tests.
Results: In eleven patients cortisol levels has not been supressed under 1.8 μg/dl after overnight 1 mg DST. Overnight 2 mg DST cortisol levels were supressed under 1.8 μg/dl in these four patients. The remaining seven patients (five women, two men) CS were confirmed with a standard 2-day, 2-mg DST, and high late-night salivary cortisol levels (2.6%). While six of them were ACTH-dependent CS, only one were adrenal CS. Mean BMI of CS patients was 38.3 kg/m2, the remainings mean BMI was 38.8 kg/m2. There was four predibaetes and two diabetes mellitus patients in CS group. Four of CS patients were hypertensive.
Conclusion: We found prevalence of CS 2.6% in overweight and obese patients whether or not accompanying overt DM or HT. Overnight 2 mg DST results yielded more specific results than 1 mg DST. Based on these results we consider screening CS with 2 mg DST in this population may be reasonable.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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