ECE2015 Eposter Presentations Pituitary: basic and neuroendocrinology (62 abstracts)
Plasma β-endorphins level is higher in lean patients with polycystic ovary syndrome than in lean women without this disorder
Marta Kialka 1 , Magdalena Spalkowska 2 , Tomasz Milewicz 1 , Anna Pelka 3 , Barbara Wasyl 4 , Iwona Rogatko 5 & Rita Tomczyk 1
1Department of Gynecological Endocrinology, Collegium Medicum, Jagiellonian University, Cracow, Poland, 2Department of Dermatology, Collegium Medicum, Jagielonian University, Cracow, Poland, 3Internal Disease Department, Dietl Specialist Hospital, Cracow, Poland, 4Department of Pediatrics, L. Rydygiera Hospital, Cracow, Poland, 5Department of Clinical Biochemistry, Polish-American Institute of Pediatrics, Cracow, Poland.
Introduction: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory and infertility. According to the widespread data it affects 3–10% of women in the procreative age. Although many research have been done, it is still unclear which of mechanisms are responsible for the development of PCOS. The most up-to-date scientific trial indicates that the evolution of PCOS is related to the activity of the endogenous opioid system but precise mechanism is not completely understood.
Description of methods/design: 26 lean women (BMI=21.34±1.83) were enrolled to the study and divided into two groups: group A consisted of 12 PCOS patients with FAI>5 and group B consisted of 14 women without features of PCOS and with FAI<5. Standard diagnostic hormone profile was made in all the patients and the level of β-endorphins was measured. The following hormones were measured: FT3, TSH, FT4, aTPO, aTG, LH, estradiol, testosterone, cortisol, DHEAS, prolactin in metoclopramide test, insulin in OGGT test, vitamin D3, C-peptide, CA125. BMI was assessed.
Results: Mean β-endorphin levels was significantly higher in group with FAI>5 (14.73 pg/ml±4.97 vs 7.26 pg/ml±2.62; Mann–Whitney test; P=0.000018). Spearman test indicated also a positive correlation between β-endorphin level and weight (r=0.682; P<0.05) and β-endorphin level and C-peptide level (r=0.778; P=0.05) in FAI<5 group. Absence of the significant correlation was observed in FAI>5 group. It might be a consequence of limited number of this group.
Conclusion: Our study showed that the level of β-endorphins was statistically significant higher in patients with PCOS. Further experimental research is required to evaluate the correlation between β-endorphins and PCOS evolution.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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