ECE2015 Eposter Presentations Obesity and cardiovascular endocrinology (108 abstracts)
IGF-1 levels correlate with T3 status in chronic heart failure outpatients: preliminary data
Vincenzo Triggiani 1 , Massimo Iacoviello 2 , Marta Leone 2 , Vito Angelo Giagulli 1 , Edoardo Guastamacchia 1 , Andrea Salzano 3 , Emanuele Bobbio 3 , Michele Arcopinto 4 & Antonio Cittadini 3
1Unit of Endocrinology, Interdisciplinary Department of Medicine, University of Bari, Bari, Italy; 2Unit of Cardiology, Department of Emergency and Organs Transplantation, University of Bari, Bari, Italy; 3Department of Translational Medical Science, Federico II University, Naples, Italy; 4Department of Cardiac Surgery, IRCCS, Policlinico S. Donato, Milan, Italy.
Background: A variety of hormones may be down-regulated in CHF patients. Impaired activity of the GH/IGF-1 axis has been described and is associated with poor clinical status and outcome. Moreover, a decrease in serum T3 is correlated to the severity of the heart disease as assessed by the NYHA classification. Aim of this study was to evaluate a possible correlation between IGF-1 levels and T3 status in a cohort of CHF outpatients.
Materials and methods: Forty-eight consecutive CHF outpatients (79% males; age 61±13 years; BMI 29±5 kg/m2; NYHA class 2.3±0.6; 47% with ischemic disease), in stable clinical conditions from at least 30 days, in conventional electrical and medical therapy (87% taking ACE-inhibitors or angiotensin receptor blockers, 96% β blockers, 96% diuretics, 72% anti-aldosterone drugs, 13% digitalis, 14% nitrates), were enrolled in the study. They were submitted to physical examination, electrocardiography and echocardiography. Blood samples were drawn to assess renal function, Na+, haemoglobin, NT-proBNPs, fT3, fT4, TSH, IGF-1, testosterone, DHEA and insulin levels.
Results: At univariate analysis, IGF-1 showed a direct correlation with fT3 and the same was found between IGF-1 levels and fT3/fT4 ratio, whereas no correlation was found between IGF-1 and the other measures. Furthermore, at multivariate analysis, including also NHYA class, fT3 was the only independent predictor of IGF-1 levels. The figure below shows a direct correlation between IGF-1 levels and both fT3 levels and fT3/fT4 ratio.
Conclusions: Impaired IGF-1 and fT3 status may both represent a derangement strictly correlated to the severity of the clinical condition in CHF.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more