Endocrine Abstracts

Diabetes is associated with a greatly increased risk of cardiovascular disease and the advanced glycation end products (AGEs) and their receptors play an important role in these complications.

Objective: To study the association between AGEs and sRAGE levels with cardiovascular risk factors in obese and non-obese newly diagnosed type 2 diabetic patients.

Material and methods: We conducted a cross-sectional study in subjects with type 2 diabetes mellitus of recent diagnosis, by means of a glucose tolerance test according to the ADA criteria (age 35–65). We studied two groups, one with obesity (n=40) and other with normal weight (n=40). We measured somatometric variables, SBP, DBP, glucose, HbA1c, lipid profile, insulin, HOMA-IR, serum AGEs, ICAM-1, VCAM-1, 8-oxo-DG, MDA, and sRAGE. We also measured carotid intima–media thickness (cIMT) and flow-mediated dilation (FMD) by ultrasound.

Results: We studied 80 patients with average age: 48±7.3 years old and HbA1c: 6.53±1.08. Serum AGEs (P<0.0001), sRAGE (P<0.0001), ICAM-1 (P<0.0001), VCAM-1 (P<0.0001), 8-oxo-dG (P<0.0001), MDA (P<0.00), HOMA-IR (P<0.001), and cIMT (P<0.001), were lower in the non-obese than in obese patients, while FMD (P<0.02) was higher in the obesity group. In the total group serum AGEs was associated with age (P<0.02), ICAM-1 (P<0.0001), and HOMA-IR (P<0.01); in the obesity group, sAGEs were associated with age (P<0.01), HbA1c (P<0.01), HOMA-IR (P<0.0001), and in the normal weight subjects with FMD (P<0.001). In the total group sRAGE were associated with VCAM-1 (P<0.0001), ICAM-1 (P<0.001), MDA (P<0.001), and cIMT (P<0.001); in the obesity group with HbA1c (P<0.02), VCAM-1 (P<0.02), MDA (P<0.0001), and 8-oxo-DG (P<0.00001).

Conclusion: The results show association of serum AGEs with ICAM-1 and HOMA-IR and strong association of sRAGE with VCAM-1, ICAM-1, MDA, and cIMT.

Disclosure: Supported by Grant of FOMIX-GTO (GTO-2012-C03-195211).