Endocrine Abstracts

Introduction: Accumulating evidence indicate that high PTH resulting from primary or secondary hyperparathyroidism, is associated with hypertension, insulin resistance, dyslipidaemia, obesity, and cardiovascular mortality. Here, we aimed to show whether high PTH levels in obese population contribute the metabolic complications of obesity.

Methods/design: The medical records of all subjects attending the obesity outpatient clinic of Kartal Dr Lutfi Kirdar Training and Research Hospital in Istanbul between April 2014 and January 2015 were retrospectively evaluated. Subjects who had chronic illness, endocrine disease (diabetes mellitus, thyroid dysfunction, Cushing disease) and subjects with any medication were excluded. A total of 400 obese patients included in the study. Anthropometric, bioelectrical bioimpedence measures, blood examinations and 75-g glucose tolerance tests results were evaluated. Data are presented as means±S.D.s for continuous or median (25 and 75% interquartiles) for non-normally distributed variables.

Results: Of the 400 obese subjects 335 were female. Mean age was 39±10. Median BMI was 36 (34–41). Subjects were divided to quartiles according to blood PTH levels. Groups included Quartile 1 (n=100, median PTH; 42 (36–45)), Quartile 2 (n=100, median PTH; 55 (51–59)), Quartile 3 (n=100, median PTH; 73 (68–78)), Quartile 4 (n=100, median PTH; 99 (89–125)). Quartiles were evaluated with generalized linear model adjusted for age, sex and season of recruitment. Log was performed for non-normally distributed variables. Systolic and dystolic blood pressure, HOMA-IR, insulin sensitivity index (ISI), triglyceride (TG), HDL-cholesterol were not different among quartiles. Although, BMI was not different (P=0.05), trunk mean body fat (MBF) and percent trunk fat (PTF) were statistically different among quartiles (P=0.03, P=0.01, respectively).

Conclusion: Serum PTH adjusted for age, sex and season of recruitment, is positively associated with trunk MBF and PTF, but was not associated with obesity linked metabolic parameters.