ECE2015 Eposter Presentations Obesity and cardiovascular endocrinology (108 abstracts)
Anti-obesity effect of Aster spathulifolius Maxim extract
In-Jin Cho 1 , Se Young Choung 2 , Do Un Kim 3 , You-Cheol Hwang 1 , Kyu Jeung Ahn 1 , Ho Yeon Chung 1 & In-Kyung Jeong 1
1Department of Endocrinology and Metabolism, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Republic of Korea; 2College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea; 3Newtree. Co., Ltd, Seoul, Republic of Korea.
Purpose: Aster spathulifolius Maxim is one of plants of chrysanthemum, which has shown an anti-obesity activity in diet induced mice model. We performed clinical trial for evaluating the anti-obesity efficacy and safety of Aster spathulifolius Maxim extract on obese human.
Methods: This study was randomised, double-blind, placebo-controlled clinical trial in Korea. A total of 41 obese subjects (BMI 25–30 kg/m2) aged ≥20 years were randomized to one of two groups: i) placebo group (n=20), ii) Aster spathulifolius extract (AE) 700 mg/day (n=21). All subjects were instructed to take a pill of once-daily regimen for 12 weeks. Weight, BMI, waist circumference, fat mass (measured by bioimpedance method, DEXA, and abdominal computed tomography (CT)), and laboratory test were assessed at baseline and 12 weeks.
Results: Body weight was significantly decreased in AE group after 12-week treatment (placebo vs. AE: −0.08±2.11 kg vs −3.30±3.15 kg, n<0.05). Body fat mass reduction was significantly shown in AE group after 12-week treatment (placebo vs AE; bioimpedance method: −0.51±1.89 kg vs −2.38±2.30 kg, P<0.05; DEXA: 0.38±1.59 kg vs −2.26±2.37 kg, P<0.05; visceral fat area in CT: 8.11±18.13 vs −24.9±37.0 cm.sp, P<0.05; subcutaneous fat area in CT: 5.51±34.58 vs −24.4±31.8 cm.sp, P<0.05). Reduction of apo-B was significantly observed in AE group compared with placebo group (placebo vs AE: 7.42±20.65 vs −2.76±15.86 mg/dl, P<0.05). The changes of fasting plasma glucose and HbA1c did not differ between two groups. In safety, there were no drug-related adverse events during the study.
Conclusion: In conclusion, Aster spathulifolius Maxim extract significantly decreases body weight, body fat, and apo-B level in obese human.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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