Endocrine Abstracts

Backgrounds and aim: Epidemiologic evidence suggests that people with diabetes are at significantly higher risk for many forms of cancer. The aim of the research was to identify cancer incidence distribution in Belarusian patients with type 2 diabetes mellitus.

Methods: The study group included 73 patients: 46 (63%) women (mean age 65±8 years) and 27 (37%) men (70±7 years) with concurrent diabetes and cancer treated at Alexandrov National Cancer Centre of Belarus in 2013. The mean time of type 2 diabetes mellitus course before cancer diagnosis was 7.8±5.8 years. A meaningful associations between diabetes and cancer incidence in men and women subgroups were analysed.

Results: Among women breast cancer was the leading malignancy, accounting for 59% (27 patients), corpus uteri cancer mentioned in 15% (seven patients), cervix in 7% (three patients), lung in 4% (two patients), and other localizations occurred in 15% (seven patients). In men subgroup the higher incidence were registered for lung and prostate cancers, accounting 22% (six cases) and 19% (five cases) accordantly, stomach cancer revealed in 15% (four persons), bladder 11% (three persons), kidneys 7% (two persons), and other localisations 26% (seven persons). Multiple primary malignancies were diagnosed in 18% (ten women and three men). The most frequent initial cancer types were women breast (five patients), lung (two patients), and corpus uteri (two patients), the other types made stomach, colon, cervix uteri cancer, and myeloleucosis.

Conclusion: Breast cancer was the predominated neoplasm (59%) in women with diabetes mellitus. The most common cancer in males was lung cancer (22%) and prostate cancer (19%). 18% of the patients with type 2 diabetes mellitus had multiple primary malignancies. Future researches are needed for better understanding of possible biologic links between diabetes and cancer risk.