ECE2015 Eposter Presentations Obesity and cardiovascular endocrinology (108 abstracts)
Galectin-3 and fibulin-1 in systolic heart failure patients with and without diabetes: relation to glucose metabolism and left ventricular contractile reserve
Pernille Holmager 1 , Michael Egstrup 2 , Ida Gustafsson 3 , Morten Schou 4 , Jordi Dahl 5 , Lars Melholt Ramussen 6 , Jacob Møller 5 , Christian Tuxen 7 , Jens Faber 1, & Caroline Kistorp 1,
1Department of Medicine, Herlev University Hospital, Herlev, Denmark; 2Department of Cardiology, Rigshospitalet, Copenhagen, Denmark; 3Department of Cardiology, Hvidovre University Hospital, Hvidovre, Denmark; 4Department of Cardiology, Herlev University Hospital, Herlev, Denmark; 5Department of Cardiology, Odense Univeristy Hospital, Odense, Denmark; 6Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark; 7Department of Cardiology, Bispebjerg Hospital, Copenhagen, Denmark; 8Faculty of Health and Science, Copenhagen University, Copenhagen, Denmark.
Aims: Diabetic patients with heart failure (HF) have an adverse prognosis, which could be linked with reduced left ventricular (LV) contractile reserve. Galectin-3 (Gal-3) and fibulin-1 are potential biomarkers of fibrosis. The aims were to evaluate the impact of DM on Gal-3 and fibulin-1 levels and the association to LV contractile reserve in HF patients with and without diabetes (DM).
Methods and results: From an out-patient HF clinic 155 patients with systolic HF were included and underwent a low-dose dobutamine echocardiography and blood sampling for analyses of plasma Gal-3 and fibulin levels. Oral glucose tolerance test (OGTT) was performed in non-diabetic HF patients. Based on history of DM and OGTT patients were divided into normal glucose tolerance (NGT) (n=95), impaired glucose tolerance (IGT) (n=25), and DM (n=60).
Results: Galectin-3 levels were 17.9 ng/ml in diabetics (P=0.02) while fibulin-1 levels were not influenced by DM status. Gal-3 was associated with LV contractile reserve in a univariable regression model; standardized β (S.E.M.) (β=−0.19, P=0.03), but not in a multivariable model including eGFR, (β=−0.04, P=0.66). Fibulin-1 was not associated with LV contractile reserve in a univariable model (β=−0.06, P=0.51). HbA1c was independently associated with Gal-3 (β=0.16, P=0.02) and fibulin-1 (β=0.16, P=0.04) in a multivariable regression model including eGFR.
Conclusion: Gal-3 and fibulin-1 levels were elevated in diabetic HF patients, associated with HbA1c, but not with LV contractile reserve.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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