ECE2015 Eposter Presentations Obesity and cardiovascular endocrinology (108 abstracts)
Glycolysis in septic patients during early ICU hospitalisation shows differences vis-a-vis shock resolution
Ioannis Ilias 1 , Sofia Apolonatou 2 , Nikitas Nikitas 2 , Maria Theodorakopoulou 2 , Frantzeska Frantzeskaki 2 , Dimitra Vasiliadi 3 & Ioanna Dimopoulou 2
1Department of Endocrinology, E Venizelou Hospital, Athens, Greece; 2Second Department of Critical Care Medicine, University of Athens Medical School, Attikon University Hospital, Athens, Greece; 3Second Department of Internal Medicine, University of Athens Medical School, Attikon University Hospital, Athens, Greece.
Introduction: In glycolysis, glucose is converted into pyruvate. Patients with sepsis are prone to numerous metabolic alterations, including changes in carbohydrate metabolism.
Aim: To assess glucose metabolism in septic patients during the first day of ICU hospitalisation and evaluate this vis-à-vis shock resolution.
Subjects and methods: Ten patients with septic shock during the first day of ICU hospitalization were studied; measurements were done every 2 h in blood for glucose and in tissue (with microdialysis (MD)) for pyruvate. Patients with diabetes were excluded. Six patients recovered from shock within 1–9 days. We analyzed the data on a cross-correlation matrix of 2-h’ increments of blood glucose and MD pyruvate for patients with shock resolution and no shock resolution separately.
Results: In patients with shock resolution significant correlations were noted for blood glucose vs MD pyruvate (maximum r: +0.96, P: 0.004; with pyruvate lagging by 12 h); no significant correlations between blood glucose and MD pyruvate were measured in the patients with no shock resolution.
Discussion: During the first day of ICU hospitalisation septic shock patients who eventually resolved their shock status showed active glycolysis, whereas patients who remained in shock had early on no appreciable glycolysis.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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