Endocrine Abstracts

The aim of the study was to evaluate frequency of cardiovascular events (myocardial infarction, stroke) among the individuals with metabolic syndrome (MS).

Materials and methods: The study design was prospective. It was started in 2003 to assess the risk factors, clinical components, diagnostic criteria of MS and to determine correlation between MS and neuropsychiatric disorders. At the second stage in 2013 the individuals were repeatedly invited to evaluate cardiovascular pathology that was confirmed by cardiologist and neurologist. The 45 years old and older citizens of Lithuanian district participated in the study. 1115 individuals (562 men and 553 women) were randomly selected in 2003. 538 respondents: 278 (51.70%) men and 260 (48.30%) women participated in the repeated study in 2013. The age of the individuals was 55 to 92 years.

Results: During the study myocardial infarction (MI) was confirmed to 40 (7.43%) individuals taken part in the study, stroke – to 23 (4.28%) individuals. The odds ratio of MI between individuals with MS and without MS was 1.80 (95% CI 1.67–1.97), P<0.05. The odds ratio of stroke for individuals with MS and without MS was 2.05 (95% CI 1.21–2.54), P<0.05. According to data of the study, occurrence of MI was higher in the group of individuals with MS than to individuals without MS, respectively 23; 9.75% vs 17; 5.63%, P> 0.05. Occurrence of stroke was higher in the group of individuals with MS, accordingly 14; 5.93% vs 9; 2.98%, P>0.05. Comparing the frequency of MI between genders, the pathology was found more frequently in women’s group: 14; 10.30% vs 9; 9.00%, P>0.05. The frequency of stroke was equal in both groups, accordingly 7; 5.15% vs 7; 7.00%, P> 0.05.

Conclusion: Individuals with identified MS have 1.80 and 2.05 times higher statistically significant probability, respectively, for MI and stroke events, than individuals without MS.