ECE2015 Eposter Presentations Obesity and cardiovascular endocrinology (108 abstracts)
The relationship between the subclinical target organ damage and the levels of ischemia-modified albumin in hypertensive patients
Nihal Ozkayar 1 , İhsan Ates 1 , Fatma Akyel 1 , Cüneyt Tayman 2 , Mehmet Namuslu 3 , A Nurdan Barça 4 , Serdar Akyel 5 & Fatih Dede 1
1Ankara Numune Education and Research Hospital, Ankara, Turkey; 2Department of Neonatology, Denizli Denizli Goverment Hospital, Denizli, Turkey; 3Department of Medical Biochemistry, Turgut Ozal University Medical School, Ankara, Turkey; 4Department of Radiology, Ankara Numune Education and Research Hospital, Ankara, Turkey; 5Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Aim: To investigate the relationship between the presence of subclinical target organ damage (STOD) and the levels of ischemia-modified albumin (IMA) in hypertensive patients.
Methods: The study included a total of 106 patients, 53 with STOD and 53 without STOD. STOD was deemed present if fundus examination revealed a grade 3–4 retinopathy; the left ventricular mass index (LVMI) was >95 g/m2 in females and >115 g/m2 in males at echocardiography; carotid intimal media thickness (CIMT) was ≥0.9 mm; and 24-h urine had 30–300 mg albumin. IMA levels were assessed by spectrophotometric method using albumin cobalt binding test. All patients underwent ambulatory blood pressure monitoring (ABPM) for 24-h.
Results: The mean whole-day systolic blood pressure was higher in patients with STOD (128.19±15.9 vs 118.55±10.5, respectively P=0.001). The mean diastolic blood pressure was similar in both of the groups (P>0.05). The mean IMA level was higher in patients with STOD (0.63±0.09 vs 0.53±0.1 respectively P=0.013).
Conclusion: Elevated IMA in patients with STOD is consistent with the role of ischemia and oxidative stress in development of target organ damage in hypertensive patients, and suggests that IMA can be used as an indicator to predict the presence of STOD.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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