Endocrine Abstracts

Introduction: Morbid obesity (MO) is associated with high frequency of type 2 diabetes mellitus (T2DM). Biliopancreatic diversion (BPD) is bariatric operation that results in rapid T2DM remission and increased GLP-1 levels. The aim of the study was to compare non-diabetic MO patients with normal weight controls and with patients who underwent BPD more than 2 years ago.

Methods: Blood glucose levels, IRI, GLP-1, GIP and glucagon were measured during the oral glucose tolerance test (OGTT) in three groups of patients. Patients of the 1st group (MO) had BMI >40 (n=22) and no history of diabetes mellitus. Patients after BPD were included in the 2nd group (n=23), post-operative period median was 4.7 years (2.3–7.2). The 3rd group were normal weight controls (n=22).

Results: Impaired glucose metabolism was revealed in 68.2% of MO patients (n=10). In MO group fasting glucose, IRI and HOMA-IR were maximal (P<0.001). MO patients had higher fasting and stimulated GIP and glucagons levels. In the BPD patients postprandial glucose (120 min) was lower, in 17.4% we found postprandial hypoglycemia (<2.8 mmol/l). Stimulated IRI concentration was significantly higher in the BPD group (P=0.026). Fasting and stimulated GLP-1 were significantly higher in BPD (P=0.037 and P=0.022, respectively).

Conclusion: Hyperglucagonaemia, increased GIP levels and decreased GLP-1 levels are observed in MO. Glucose intolerance and insulin resistance incidence is higher in MO patients. Stimulated plasma IRI and GLP concentrations are significantly increased in BPD patients.

Disclosure: This work was supported by the Russian Foundation for Basic Research (grant &#8470; 11-04-00946).