Bone mineral density in patients with type 1 diabetes mellitus by DEXA and QCT

Eleftheria Mparmpa; Spyros Karamagiolis; Stelios Tigas; Parthena Navrozidou; Marianna Vlychou; Ioannis Fezoulidis; Georgios N Koukoulis; Alexandra Bargiota

doi:10.1530/endoabs.37.EP526

EP526

Prev Next

Section Contents Cite

Endocrine Abstracts (2015) 37 EP526 | DOI: 10.1530/endoabs.37.EP526

ECE2015 Eposter Presentations Diabetes (complications & therapy) (143 abstracts)

Bone mineral density in patients with type 1 diabetes mellitus by DEXA and QCT

Eleftheria Mparmpa ¹ , Spyros Karamagiolis ² , Stelios Tigas ³ , Parthena Navrozidou ⁴ , Marianna Vlychou ⁴ , Ioannis Fezoulidis ⁴ , Georgios N Koukoulis ¹ & Alexandra Bargiota ¹

Err

Author affiliations View ePoster Download ePoster

¹Department of Endocrinology and Metabolic Diseases, University of Thessaly, Larissa, Greece; ²General Hospital of Larissa, Larissa, Greece; ³Department of Endocrinology, University of Ioannina, Ioannina, Greece; ⁴Department of Radiology, University of Thessaly, Larissa, Greece.

Introduction: Type 1 DM (T1DM) has been associated with low bone mineral density (BMD) measured by dual energy X-ray absorptiometry (DEXA) but not with quantitative computed tomography (QCT). QCT provides a three-dimensional image and measures bone’s volume directly as density, independent of the surrounding tissues. The purpose of this study was to evaluate BMD in patients with T1DM using DEXA and QCT.

Methods/design: We studied 81 patients with T1DM (group D) (age: 36+9.7 years, M/F: 32/49) and 70 healthy controls (group C) matched for age, sex, and BMI. In both groups, we measured HbA1c, lumbar spine (LS), and femoral neck (FN) BMD by DEXA and LS BMD by QCT.

Results: Mean BMI (kg/m²) was similar in both groups (D: 23.3+8.1 vs C: 23.7+8.3, P=0.39). In group D, mean duration of diabetes was 16.1+9.9 years and mean HbA1c was 8.1+1.3%. BMD (g/cm²) and z-score measured by DEXA were lower in group D compared to group C at LS (1.02±0.20 vs 1.05±0.14, P=0.03) (−0.31±1.61 vs 0.78±1.76, P=0.01) and at FN (0.69±0.12 vs 0.89±0.11, P=0.043) (−0.1+1.47 vs 1.35±1.04, P=0.037). Also, LS z-scores measured by QCT were lower compared to DEXA (D: −0.16+1.08 vs −0.31±1.61, P=0.022). The lower DEXA z-scores were negative correlated with young onset age (r=−0.74, P=0.021) and longer duration of T1DM (r=−0.78, P=0.032) but not with glycaemic control (r=0.36, P=0.18). In group D, DEXA detected 9/81 patients (11.1%) with osteopenia and 1/81 with osteoporosis (1.2%) at LS and 5/81 (6.2%) with osteopenia and 1/81 with osteoporosis (1.2%) at FN. In contrast, QCT has detected 14/81 patients (17.3%) with osteopenia and 2/81 patients (2.5%) with osteoporosis at LS.

Conclusion: T1DM is associated with lower BMD compared to controls with both methods used. The choice of measuring method may define a different degree of bone loss.