Endocrine Abstracts

Objective of the study was to analyse the relationship of compensation, lipid profile parameters and androgenic status in patients with type 1 (DM1) depending on the duration of diabetes. There were examined 76 men with DM1 aged 20–49 years (mean age 35.8±8.2) and duration of diabetes more than a year. The control group consisted of 25 healthy men aged 21–41 years (mean age 34.6±7.8). Compensation of diabetes was assessed by the level of HbA1c. Also there were assessed the lipid profile parameters (total amount of cholesterol and triglycerides), total testosterone, FSH, LH, prolactin hormone, sex hormone binding globulin, and homocysteine. Statistical analysis of the data was performed using the software package Microsoft Exel 2003 (SPSS 17.0).

It has been determined that at the absence of compensation in patients with DM1 (HbA1c 8.3±1.4%), with the increasing duration of diabetes there was noticed the increasing of BMI: a group with DM <10 years, 24.6±3.9 kg/m², the group with DM >10 years, 27.6±4.4 kg/m² (P=0.01), progression of lipid storage disease (increased level of triglycerides: 1.4±1.1 mmol/l vs 3.7±1.3 mmol/l in the group with DM >10 years (P=0.01)). We were not found the difference in levels of total cholesterol, LH, FSH, prolactin hormone, sex hormone binding globulin, and homocysteine. The absence of androgenic status disorders and changes of homocysteine level are probably associated with the young age of patients, a slight excess of weight and a lack of decrease in GFR. The detected changes are important risk factors of development and progression, and require appropriate arrangements, including the correction of body weight and secondary dyslipidaemia.