Endocrine Abstracts

Introduction: Diabetes mellitus is an important public health problem due to defects of the effect of the insulin or insulin deficiency, accompanied by chronic microvascular complications with diabetic nephropathy is characterised by proteinuria that the increasing number of patients progress to end stage renal disease. Many peptide hormone made in etiopathogenesis is situated, although adropin which discovered in recent years involves in glucose homeostasis, its relation to diabetes and nephropathy has still not been investigated. Thus, in this research, the determining of serum and urine levels of adropin in diabetic patients, the relationship between adropin and diabetes mellitus with diabetic nephropathy were aimed to investigate.

Methods: The serum and urine levels of adropin in 20 healthy individuals to form a control group with total of 60 diabetic patients including normoalbuminuric 20, microalbuminuric 20, and overt albuminuric 20 ones were measured.

Results: Serum adropin levels compared with the overt albuminuric group were significantly as lower in healthy control, normoalbuminuric, and microalbuminüric groups (respectively; P=0.007, P<0.001, and P=0.008). Adropin were found to be positively correlated with serum creatinine and microalbuminuria levels (respectively; P=0.031, r=0.242 vs P=0.001, r=0.379). Adropin urine levels were significantly as higher in diabetic patients than in healthy controls (P=0.001). Compared with the normo and overt albuminuric groups, adropin urine levels were lower in microalbuminuric group (P=0.026 for both).

Discussion: As a result, the serum adropin levels appear to be increased in overt albuminuric group. The cause of increased activity of these peptides associated with endothelial function and energy homeostasis can be considered for renal hemostasis. Urinary adropin levels to be lower only in the diabetic microalbuminuric group, can be identified triggering factor clinically at the initial phase of diabetic nephropathy due to the fact that a peptide hormone.