ECE2015 Eposter Presentations Diabetes (complications & therapy) (143 abstracts)
SE Institute of Endocrinology and Metabolism named after V.P. Komissarenko National Academy of Medical Science of Ukraine, Kyiv, Ukraine.
Erectile dysfunction (ED) frequent disease that accompanies diabetes or is its complication. According to various reports the prevalence of ED in males with type 2 diabetes (T2DM) varies from 25 to 90%. In recent years, the ED is considered as predict factor in the development of T2DM in men and as a marker of vascular complications progression.
Aim: To examine the state of androgens in men suffering from T2DM and erectile dysfunction.
Material and methods: We observed 205 male patients (48±4.6 years) with T2DM (HbA1c did not exceed 6.5%) with complaints on ED. Erectile function was determined with international index of erectile function scale. Levels of total testosterone (tT), estradiol (E2), and LH in blood serum were measured with immunoferment method. The controls 24 healthy men without diabetes and ED (2558 years).
Results: The average index of erectile function scored 17.23±2.08 points and was lower than in the controls 26.75±0.79 (P<0.01). Satisfaction with sexual intercourse was reduced compared with the controls (9.34±0.93 vs 16.18±0.68 points (P<0.01). Orgasmic feelings and sexual desire were lower in T2DM patients than is controls (6.48±0.72 vs 9.23±0.26 points (P<0.05) and 9.44±0.95 vs 13.93±0.56 points (P<0.01) respectively). The index of erectile function in T2DM patients studied showed moderate ED in 62.4% cases (15.1±0.68) and severe ED in 22.4% of patients (12.2±0.44). Levels of tT in group 4150 years was 3.1±0.47 ng/ml, 5160 years was 2.7±0.71 ng/ml, and >60 years was 2.9±0.55 ng/ml vs 5.63±0.9 ng/ml and were lover than in control (5.63±0.9 ng/ml). Serum levels of E2 in patients did not differ from the controls (0.17±0.04 pmol/l vs 0.14±0.02 pmol/l), as well as LH concentrations (4.28±0.36 IU/l vs 4.2±0.5 IU/l).
Conclusions: Low testosterone is an important pathogenic factor in the development of ED in men with T2DM.