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Endocrine Abstracts (2015) 37 EP440 | DOI: 10.1530/endoabs.37.EP440

ECE2015 Eposter Presentations Diabetes (complications & therapy) (143 abstracts)

Low testosterone and erectile function in male patients with type 2 diabetes

Vitaliy Luchytskiy & Eugen Luchytskiy


SE ‘Institute of Endocrinology and Metabolism named after V.P. Komissarenko National Academy of Medical Science of Ukraine’, Kyiv, Ukraine.


Erectile dysfunction (ED) – frequent disease that accompanies diabetes or is its complication. According to various reports the prevalence of ED in males with type 2 diabetes (T2DM) varies from 25 to 90%. In recent years, the ED is considered as predict factor in the development of T2DM in men and as a marker of vascular complications progression.

Aim: To examine the state of androgens in men suffering from T2DM and erectile dysfunction.

Material and methods: We observed 205 male patients (48±4.6 years) with T2DM (HbA1c did not exceed 6.5%) with complaints on ED. Erectile function was determined with international index of erectile function scale. Levels of total testosterone (tT), estradiol (E2), and LH in blood serum were measured with immunoferment method. The controls – 24 healthy men without diabetes and ED (25–58 years).

Results: The average index of erectile function scored 17.23±2.08 points and was lower than in the controls – 26.75±0.79 (P<0.01). Satisfaction with sexual intercourse was reduced compared with the controls (9.34±0.93 vs 16.18±0.68 points (P<0.01). Orgasmic feelings and sexual desire were lower in T2DM patients than is controls (6.48±0.72 vs 9.23±0.26 points (P<0.05) and 9.44±0.95 vs 13.93±0.56 points (P<0.01) respectively). The index of erectile function in T2DM patients studied showed moderate ED in 62.4% cases (15.1±0.68) and severe ED in 22.4% of patients (12.2±0.44). Levels of tT in group 41–50 years was 3.1±0.47 ng/ml, 51–60 years was 2.7±0.71 ng/ml, and >60 years was 2.9±0.55 ng/ml vs 5.63±0.9 ng/ml and were lover than in control (5.63±0.9 ng/ml). Serum levels of E2 in patients did not differ from the controls (0.17±0.04 pmol/l vs 0.14±0.02 pmol/l), as well as LH concentrations (4.28±0.36 IU/l vs 4.2±0.5 IU/l).

Conclusions: Low testosterone is an important pathogenic factor in the development of ED in men with T2DM.

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