ECE2015 Eposter Presentations Diabetes (complications & therapy) (143 abstracts)
Particular characteristics of breath during night sleep in type 1 diabetes patients
Ina Darashkevich 1 , Tatsiana Mokhort 2 , Lola Nikonova 1 , Serhej Tishkovsky 1 & Elina Davydchik 1
1Grodno State Medical University, Grodno, Belarus; 2Belorussian State Medical University, Minsk, Belarus.
Objective: Assessing the impact of glycaemic control on indicators of breathing during night sleep in type 1 diabetes patients.
Methods: Continuous blood glucose monitoring by ‘SGMSGold’ (Medtronik MINIMED) with estimation of average glycaemic value (AG) and other parameters; polysomnographic monitoring by ‘SOMNOlab 2 (PSG) Polysomnography (R&K)’. Group 1 included patients with AG levels <8.0. Group 2: AG >8.0 mmol/l regardless of HbA1c (7.50 (5.00–9.40) and 8.01 (5.60–12.00)% respectively).
Results of the study: The differences in the characteristics of sleep and periods of hyperglycaemia, normoglycaemia, AG, MGL in the comparison groups were detected. There was an inverse relationship between AG <8.0 mmol/l and the mean respiratory rate TST, deep sleep S4 stage (r=−0.64), sleep latency (r=−0.58); direct correlation between amount of apnoea (r=0.74 and r=0.90); MGL with the duration of slow wave sleep (r=−0.61) and reverse with RE NREM (r=0.57).
| Indicator | Group 1, mean (min–max) | Group 2, mean (min–max) |
| Amount (n) | 13 | 20 |
| Age | 34.5 (25.0–54.0) | 35.9 (20.0–56.0) |
| The average value of blood glucose (AG) (mmol/l) | 6.6 (3.2–8.0)* | 10.0 (8.1–16.6) |
| Hyperglycaemia (%) | 11.5 (0.0–22.0)* | 43.5 (10.0–86.0) |
| Hypoglycaemia (%) | 14.4 (0.0–80.0)* | 3.75 (0.0–25.0) |
| Normoglycaemia (%) | 74.1 (20.0–92.0)* | 52.7 (0.0–77.0) |
| The minimum glucose level during sleep (MGL) (mmol/l) | 3.7 (2.0–6.1)* | 5.8 (2.5–11.5) |
| The index of apnoea/hypopnea (AI) | 0.4 (0.3–14.8)* | 2.1 (0.0–16.4) |
| The average duration of all respiratory events (RE) during total sleep time (TST) | 25.0 (0.0–41.0)* | 15.8 (0.00–40.0) |
| *P<0.05. | ||
Conclusions: AG <8 mmol/l is associated with violations of the respiratory rate and sleep latency. It is noted that the MGL correlated with the duration of SWS, indicating that the effect of hypoglycaemia on sleep quality, the average length of all RE during TST.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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