Endocrine Abstracts

Introduction: Inflammatory markers play an important role in the development of type 2 diabetes and coronary artery disease. Monocyte chemoattractant protein-1 (MCP-1) is a member of the C-C chemokine family and a potent chemotactic factor for monocytes.

The aim of our study was to investigate the effect of MCP-1 A-2518G polymorphisms on the development of diabetic coronary heart disease.

Subjects and methods: 53 diabetic patients with coronary heart disease, 64 diabetic patients without coronary heart disease and 61 healthy controls were genotyped. Diabetes was diagnosed according to the criteria of the American Diabetes Association (ADA) and the non-diabetic subjects were selected according to no past history of diabetes mellitus or impaired glucose tolerance. PCR–RFLP method was used for genotyping.

Results: There were significant differences between diabetic patient with coronary heart disease and control groups in MCP-1 A-2518G genotype (P: 0.01%2 χ²: 9.11) and allele distribution (P: 0.01%2 χ²: 6.53). MCP-1 AA genotype was significantly increased in coronary artery patients compared with controls but MCP-1 G allele frequency was increased in controls.

Conclusion: We found that MCP-1 2518 AA genotype may associate with diabetic coronary artery disease susceptibility while G allele seems to be have protective effect against diabetic coronary disease.

Disclosure: The present work was supported by the Research Fund of Istanbul University Project No. 2874.