ECE2015 Eposter Presentations Diabetes (pathiophysiology & epitemiology) (80 abstracts)
Lipoprotein associated phospholipase A2 was not associated with diabetic rethinopathy
Zehra Candan 1 , Fatma Dilek Dellal 2 , Esranur Ademoglu Dilekci 3 , Ziynet Alphan Uc 4 , Handan Bekdemir 5 , Gonul Koc 6 , Cavit Culha 6 , Yalcin Aral 6 , Guner Uney 6 & Zuleyha Yalniz Akkaya 6
1Ankara Medical Park Hospital, Ankara, Turkey; 2Ankara Ataturk Training and Research Hospital, Ankara, Turkey; 3Bitlis State Hospital, Bitlis, Turkey; 4Usak State Hospital, Usak, Turkey; 5Izmir Sifa University Hospital, Izmir, Turkey; 6Ankara Research and Training Hospital, Ankara, Turkey.
Aim: Diabetic rethinopathy is an important microvascular complication in diabetic patients. The association between hyperlipidemia and diabetic rethinopathy remains elusive. Lipoprotein associated phospholipase A2 (Lp-PLA2) is Ca independent serine kinase that hydrolyses oxidized LDL and forms lysilphoshotidylcholine and free fatty acid. The aim of the study was to determine serum levels of Lp-PLA2, traditional lipids, apolipoproteins in patients with diabetic rethinopathy and to evaluate correlation of these parameters with disease severity.
Methods: A total of 67 diabetic patients were divided into three groups (nonproliferative diabetic rethinopathy, proliferative rethinopathy, and no rethinopathy) based on fundoscopic examination and matched to 15 healthy and nondiabetic people. Blood samples for lipids, apolipoproteins, Lp-PLA2 were drawn.
Results: No significant difference was observed in terms of total cholesterol, TG, LDL-C levels between groups. However HDL-C levels were similar in proliferative diabetic rethinopathy, nonproliferative rethinopathy patients and diabetic controls (42.5±6.4, 46.8±12.3) and were lower than healthy controls (61.1±14.5, P<0.005). No statistically significant difference was shown with respect to apolipoprotein A1, apolipoprotein B, apo B:apo A1 ratio in all comparisions. Serum levels of Lp-PLA2 was similar in all groups.
Conclusions: Serum levels of lipids, apolipoproteins and Lp-PLA2 were not associated with diabetic rethinopathy. Although, Lp-PLA2 were found to be associated with macrovascular complications of diabetes in most studies, the role of this molecule in microvascular complications wasn’t known. The larger sample sized studies may clarify the relationship between Lp-PLA2 and rethinopathy.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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