ECE2015 Eposter Presentations Diabetes (pathiophysiology & epitemiology) (80 abstracts)
Surgical trauma and insulin resistance
Snezana Polovina 1 , Dusan Micic 2 , Zlatibor Loncar 2 , Mirjana Sumarac-Dumanovic 1 , Predrag Savic 2 , Goran Cvijovic 1 , Vladimir Resanovic 2 , Svetlana Zoric 1 , Danica Stamenkovic-Pejkovic 1 , Vladimir Djukic 2 & Dragan Micic 1
1Clinic for Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center of Serbia, Belgrade, Serbia; 2Emergency Center, Clinical Center of Serbia, Belgrade, Serbia.
Introduction: Different surgical procedures are followed by alteration in insulin sensitivity. The aim of our investigation was to analysed the influence of major (open cholecystectomy) and minor surgical stress (laparoscopic cholecystectomy) on insulin resistance.
Methods: Insulin resistance was calculated by HOMA-IR before surgery and at 1st, 3rd, and 7th day after the elective operations. All participants were divided in two groups: group A with open cholecystectomy n=20; 38.8±4.3 years of age; mean BMI 26.9±1.6 kg/m2 and group B with laparoscopic cholecystectomy; n=20; 39.8±4.5 years of age; mean BMI 26.8±1.9 kg/m2.
Results: There were no difference in HOMA-IR between groups A and B before surgery (mean 2.5±0.33 vs 1.99±0.70; P>0.05) as well as the 1st day after surgery (2.55±0.62 vs 1.85±0.58; P>0.05). HOMA-IR was higher in group B 3rd day after operation than in group A (7.56±2.34 vs 2.8016±0.78; P<0.05). There were no difference between two groups 7 days after surgery (0.65±0.45 vs 0.74±0.40; P>0.05).
Conclusion: Open and laparoscopic cholecystectomy are followed by transient insulin resistance which become normal a week after the operation. Laparoscopic cholecystectomy less deteriorate insulin sensitivity in response to stress than open approach.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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