Endocrine Abstracts

Introduction: The aim of the study was to assess if gestational diabetes mellitus (GDM) influence the pregnancy outcomes and the growth patterns in children.

Design: Our prospective study cohort consisted of 261 children born to mothers with GDM and 153 control children born to non-diabetic mothers. In both groups children’s weight, length were assessed. Children were matched for large for gestational age (LGA) (birth weight >90th percentile for gestational age), appropriate for gestational age (AGA) (birth weight between the 10th and 90th percentiles), and small for gestational age (SGA) (birth weight <10th percentile) status. Children anthropometric measurements were made at 12, 18, 24, and 30 months. BMI was calculated. The overweight was diagnosed at BMI between 90 and 96 percentiles, obesity between 97 and 100 percentiles. The WHO child growth standards were implemented. The bioethics committee agreement was obtained.

Results: Among 261 GDM children, 80.5% were AGA, 10% SGA, 9.6% LGA; in control group 19% LGA. Birth weight of the child in GDM pregnancies was 3.30±0.53 kg comparing to the control children 3.42±0.54 kg, P=0.01. No changes in weight and BMI were found between groups in the 12th month of life. The weight >90 percentile at this period was observed in 34.6% children, BMI between 90 and 96 percentiles in 17.33% and between 97 and 100 percentiles in 17.33%. At the age of 18 months the weight of childrem born to GDM mothers was >90 percentle in 54.8% comparing to the control group in 29%, P=0.04; No changes were found in BMI. At the age of 24 and 30 months we found no differences in BMI in both groups.

Conclusions: We found that children who were LGA at birth were less often born to GDM mothers after implementation of dietary regiment comparing to general population. GDM did not influence the growth pattern in first 36 months of live.

Disclosure: Supported by: Polish Ministry of Science Grant Number NN404 521938.