ECE2015 Eposter Presentations Diabetes (pathiophysiology & epitemiology) (80 abstracts)
Gamma glutamyl transferase and C-reactive protein in type 2 Saudi diabetic patients in relation to management modality and components of metabolic syndrome
Suhad Bahijri 1 , Maimoona Ahmed 1 , Khalid Al-Shali 1 , Samia Bokhari 1, , Amani Alhozali 1 , Anwar Borai 1, , Amani Gusti 1, , Ghada Ajab Noor 1 , Jawahir Al Ahmadi 1 , Ahmed Alghamdi 1 , Mohammed Asiri 1 , Osamah Bashawieh 1 , Abeer Aljahdali 1 & Jaakko Tuomilehto 1,
1Saudi Diabetes Research Group, Faculty of Medicine, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; 2King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health, Jeddah, Saudi Arabia; 3King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; 4Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland.
Background: Different management modalities are used to control hyperglycaemia associated with type 2 diabetes (T2DM). Research has indicated an association of single or combined insulin therapy with increased cardiovascular events. Metabolic syndrome (MS), as well as increased levels of C-reactive protein (CRP), and gamma glutamyl transferase (GGT) are also associated with increased CVD risk.
Aim: To study the relationship between management modality, glycaemic control, components of metabolic syndrome and serum levels of GGT and CRP.
Methods: T2DM subjects were recruited from outpatients clinics at two hospitals in Jeddah. Pregnant subjects, and those having any other severe chronic illness or diabetes complications were excluded. Anthropometric measurements, and blood pressure were taken. Treatment plan was recorded. Fasting blood samples were obtained to measure glucose, HbA1c, lipids profile, CRP and GGT.
Results: A total of 153 subjects were recruited (46.4% males, 53.6% females). MS was present in 131 (85.6%) patients. In spite of significantly lower mean HbA1c in hypoglycaemic drugs users compared to means in those using single or combined insulin therapy (P<0.001), and significantly lower mean diastolic blood pressure (DBP) in insulin users (P=0.025), no significant difference was found in means of GGT or CRP. Significantly higher mean GGT was found in uncontrolled compared to controlled, and hypertensive compared to normotensive patients (P<0.05 in both cases).GGT correlated positively with triglycerides (r=0.227, P=0.028), and negatively with HDL-C (r=−0.188, P=0.049). CRP correlated positively with waist circumference (r=0.204, P=0.045), and mean value being higher in abdominally obese group compared to non-obese (P=0.048).
Conclusions: Serum GGT and CRP levels do not appear to be affected by management regimen in T2DM Saudi patients. Some components of MS, hypertension and poor glycaemic control are associated with higher levels of either CRP or GGT, hence increased cardiovascular risk.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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