Endocrine Abstracts

The mechanisms of development and progression of essential hypertension (EH) and concomitant type 2 diabetes (DM2) still remain not completely studied, so the comprehensive evaluation of the contribution of various indicators to the formation of this comorbidity have scientific interest.

The aim of the study was comprehensive assessment of the variability of anthropometric, echocardiographic and biochemical parameters in patients with EH and concomitant DM2. We examined 243 patients aged 45–60 years. The main group consisted of 153 patients with EH stage II, grade 2 and DM2 moderate, subcompensated; comparison group – 70 patients with EH stage II, grade 2 without DM2. The control group consisted of 20 healthy individuals.

Integrated data processing was carried out with the help of factor analysis using principal component. In the analysis there were 73 variables, based on the relationships among which there were four factors that together explain 52.61% of the total variability of the empirical data. In this case the first and the most powerful factor explained 33.07% of the total variability of indices. The highest load of Factor 1 were at indicators diene conjugates, malondialdehyde, tumor necrosis factor-α, interleukin-6, blood glucose, insulin, HbA1c, HOMA, leptin, intima-media thickness of the common carotid artery, while at the negative pole of this factor were superoxide dismutase, catalase, endothelium-dependent vasodilatation, adiponectin, HDL).

Averaged factor estimates for Factor 1 were: 0.517±0.025 – in the main group, −0.986±0.039 – in the comparison group and −2.476±0.037 – in the control group with highly significant differences between the factor scores in all groups (P<0.001).

Conclusion: We discovered four main factors, the general action of which explained 52.61% of variability indices in comorbid pathology – EH and DM2. Factor assessment of the most powerful Factor 1 with high significance made the studied groups of patients differ from each other.