Endocrine Abstracts

Objective: The assessment of glycemic control and concentration of lipids in the blood in patients with type 1 diabetes mellitus (DM-1), depending on the presence of depression (DP).

Methods: There were examined 163 patients with DM-1. To assess severity of DP there was used Hospital Anxiety and Depression Scale (HADS). There were determined the level of fasting blood glucose (BG), BG level in 2 hours after a meal, the average daily BG level for 3 days and HbA_1C level. Also there were determined the total amount of cholesterol (TC), triglycerides (TG), HDL cholesterol (HDL-C). The amount of LDL cholesterol (LDL-C) and the amount of very LDL cholesterol (VLDL-C) were determined by calculation.

Results: Increased level of HbA_1C was found in patients with DP, the mean daily glucose compared with patients without DP (9.70% vs 8.40%, P<0.001; 9.02 mmol/l vs 8.10 mmol/l, P=0.03 respectively). There has been established a positive correlative relationship between the level of DP according to the HADS scale and HbA_1C level (r=0.20; P<0.05), as well as between the level of DP according to the HADS scale and the level of the mean daily BG (r=0.22; P<0.05). Development of DP at DM-1 is associated with the level of HbA_1C 7.5% or more (OR=0.89; P=0.03; 95% CI 0.30–1.48). The results of evaluation of biochemical parameters characterizing lipid metabolism according to the presence of DP indicate, that the level of TC in patients with DP was higher than in patients without DP (5.10 mmol/l vs 4.80 mmol/l; P=0.04). There has also been determined that the level of LDL-C was 3.10 mmol/l in patients with DP vs 2.65 mmol/l in patients without DP and exceeded by 14.5% the value of comparison group (P=0.05).

Conclusions: The risk of development of DP in DM-1 is associated with decompensation of carbohydrate metabolism and dyslipidaemia.