The relationship between higher left ventricular mass index and plasma total homocysteine levels in patients with type 2 diabetes mellitus

Harun Kundi; Ihsan Ates; Nihal Ozkayar; F Vasfi Ulusoy

doi:10.1530/endoabs.37.EP324

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Endocrine Abstracts (2015) 37 EP324 | DOI: 10.1530/endoabs.37.EP324

ECE2015 Eposter Presentations Diabetes (pathiophysiology & epitemiology) (80 abstracts)

The relationship between higher left ventricular mass index and plasma total homocysteine levels in patients with type 2 diabetes mellitus

Harun Kundi ¹ , İhsan Ates ² , Nihal Ozkayar ³ & F Vasfi Ulusoy ¹

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¹Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey; ²Department of Internal Medicine, Ankara Numune Education and Research Hospital, Ankara, Turkey; ³Department of Nephrology, Ankara Numune Education and Research Hospital, Ankara, Turkey.

Purpose: The aim of the present study was left ventricular mass index (LVMI) in type 2 diabetes mellitus (T2DM) patients may be related increased circulating homocysteine (Hcy) levels.

Methods: The study group comprised 130 patients, and all patients were newly diagnosed with diabetes and were not taking any medication. Measures of left ventricular mass (LVM) were assessed using Devereux formula and left ventricular mass index (LVMI) was calculated as LVM divided by body surface area. Hcy levels were measured using high-performance liquid chromatography.

Results: Forty five patients (34.6%) of all patients with higher LVMI. In univariate logistic regression analyses age, creatinine and Hcy count all significantly associated with higher LVMI. When these three variables were included in a multivariate regression modeling Hcy levels were found to be significantly associated with the higher LVMI.

Conclusions: Hyperhomocysteinemia (Hhcy) can be a predictor of in T2DM patients.