ECE2015 Eposter Presentations Calcium and Vitamin D metabolism (96 abstracts)
May the polymorphism of low molecular weight protein tyrosine phosphatase modulate metabolic and bone remodelling parameters associated with osteoporosis?
Joana Freitas 1, , Cristina Monteiro 3 , Ana Paula Barbosa 2, , Fátima Batista 3 , Maria José Laires 3 , Manuel Bicho 1, & Mário Rui Mascarenhas 2,
1Institute for Scientific Research Bento Rocha Cabral, Lisbon, Portugal; 2ISAMB, FMUL, Lisbon, Portugal; 3CIPER, FMH-UL, Lisbon, Portugal; 4Clinic of Endocrinology, Diabetes and Metabolism, Lda, Lisbon, Portugal; 5Department of Endocrinology, Diabetes and Metabolism, HSMaria-CHLN, Lisbon, Portugal.
Aims: To study the association of protein tyrosine phosphatase (LMW–PTP/ACP1) polymorphism with bone mineral density and metabolic parameters of bone remodelling.
Methods: BMD (g/cm2) was measured by DEXA in 760 subjects: 448 normal BMD (359F/89M; 49.7±12.9 years; 30.2±5.4 kg/m2) and 312 osteoporosis (265F/47M; 63.9±10.4 years; 27.16±4.4 kg/m2). Metabolic bone remodelling parameters were analyzed: LDL, HDL, total cholesterol, triglycerides, HOMA, alkaline phosphatase (AP), and osteocalcin. ACP1 activity was measured by spectrophotometry. ACP1 polymorphism was evaluated by PCR.
Results: Association was found between the genetic polymorphism of ACP1 and its enzymatic activity with higher values for genotypes AC+BC, intermediate values for BB and lower values for AA+AB. Osteoporosis: i) increased LDL, total cholesterol, AP, osteocalcin and ACP1, and decreased HOMA; ii) association between genotypes BB+BC+AC and increased total cholesterol, LDL, and ACP1; and iii) positive correlation between AP and LDL, total cholesterol, and osteocalcin. Normal BMD: i) association between genotypes BB+BC+AC (intermediate and higher ACP1 activity) and increased ACP1 and decreased AP and ii) positive correlation between AP and osteocalcin and HOMA. Only correlations of AP with LDL and total cholesterol remained significant when analyzed separately AA+AB individuals.
Conclusion: In osteoporosis, ACP1 polymorphism appears to modulate some metabolic parameters associated with a decrease in BMD, including total cholesterol, LDL, and ACP1 activity.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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