ECE2015 Eposter Presentations Calcium and Vitamin D metabolism (96 abstracts)
An oral high dose of cholecalciferol restores vitamin D status in deficient postmenopausal HIV-1 infected women independently of protease inhibitors therapy
Jessica Pepe , Ivano Mezzaroma , Alessandra Fantauzzi , Mario Falciano , Alessandra Salotti , Mario Di Traglia , Daniele Diacinti , Sara Belcastro , Sara Piemonte , Cristiana Cipriani & Salvatore Minisola
Sapienza University, Rome, Italy.
Introduction: The best repletion and maintenance dosing regimens with cholecalciferol in vitamin D deficient HIV-1 patients remain unknown. Protease inhibitors (PIs) have been shown to inhibit vitamin D 1α- and 25α-hydroxylation in hepatocyte and monocyte cultures. We therefore evaluated the effect of a single high dose of cholecalciferol in vitamin D deficient HIV-1 postmenopausal women undergoing treatment with highly Active Anti-Retroviral Therapy (cART), with and without PIs.
Methods: Forty HIV-1 postmenopausal women treated with cART, with hypovitaminosis D (<20 ng/ml), were enrolled. We measured serum changes of 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), parathyroid hormone (PTH), serum calcium and urinary calcium excretion following a loading dose of 600 000 IU of cholecalciferol after 3, 30, 60, 90, and 120 days.
Results: The sample was divided according to the presence PIs (group A, n=20) or absence (group B, n=20). There were no significant differences between the two groups at baseline (mean 25(OH)D group A 13.93±3.85 vs group B 12.94±3.86 ng/ml, P=NS). The cART scheme was not modified during the study period. We did not find any significant changes in the two groups, as regards: the mean CD4 values, the HIV RNA values, and the body mass index. A significant increase in mean 25(OH)D and 1,25(OH)2D levels at day 3 and throughout the entire observation period was found in both groups (P<0.001). PTH levels concomitantly decreased in both groups (P<0.001). Mean albumin-adjusted serum calcium increases with respect to baseline were significant only at days 3 and 30 for both groups (P<0.01). There were no significant differences between the groups at any time, by two-way RM ANOVA.
Conclusions: An oral dose of 600 000 IU of cholecalciferol in HIV-1 postmenopausal women rapidly increases 25(OH)D and 1,25(OH)2D levels reducing PTH levels, regardless of the presence of PIs in the cART scheme.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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