ECE2015 Eposter Presentations Calcium and Vitamin D metabolism (96 abstracts)
Relationship between vitamin D supply and healing in patients with hip fracture
Erzsebet Toldy , Antal Salamon , Balazs Hepp , Akos Matrai , Csaba Biro , Katalin Agota , Emoke Fata & Zoltan Locsei
Markusovszky Hospital, Szombathely, Hungary.
Background: Vitamin D (VD) deficiency is important risk factor of fractures. Yet, the relation of serum 25-hydroxyvitamin D (25OHD) levels and recovery of fractures is poorly studied. Our aim was to investigate the VD supply in hip fractures also with regard to lifestyle and other clinical (malignancy, kidney and liver disease, osteoporosis) conditions.
Method: 25OHD (protein binding assay, Cobas, Roche) and parathyroid hormone (PTHi) (electrochemiluminescence immunoassay, Cobas, Roche) levels of 202 patients (67 men and 135 women) with hip fracture (age 75±12 years) and 102 age-matched persons with active lifestyle, as controls were investigated.
Results: VD deficiency and secondary hyperparathyroidism occurred significantly more frequently in patients with hip fracture than in the control group (73% vs 36% and 33% vs 12% respectively). Patients with better condition after surgery showed significantly higher 25OHD (median with interquartilis ranges: 44 (28–72) vs 15 (9–43) nmol/l; P<0.001) and lower PTHi (51 (35–64) vs 63 (48–88) pg/ml, P<0.05) levels than patients with bad condition. 31 patients who died after surgery (median survival time: 19 (5–52) days) had lower 25OHD levels than those who survived (23 (9–43) vs 33 (17–57) nmol/l) without significant difference in PTHi levels. These results were independent of chronic disorders.
Conclusion: The correlation between 25OHD levels and better postoperative condition confirm the importance of VD substitution in prevention, as well as in healing, and in increased survival rate.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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