Endocrine Abstracts

Anaemia prevalence is reported between 5 and 31.8% in patients with PHPT. Anaemia in PHPT shows correlations with serum calcium, PTH, alkaline phosphatase levels, severity of the bone disease and PHPT duration. In this study we compared pre-operative and post-operative haemogram parameters of patients with PHPT who received a parathyroidectomy at our department. We determined the prevelance of pre-operative anaemia, thrombocytopenia, neutropenia and observed if any of this parameters were recovered after the surgery. We excluded patients with systemic diseases which may interfere with cytopenias. Likewise, we determined pre-operative and post-operative variations of some parameters such as RDW, MPV, neutrophile/lymphocyte rates, that are often disregarded in haemogram reports but related to chronical inflammation. Out of 157 patients with PHPT, 127 (80.9%) were women and 30 (19.1%) were men. There was no significant difference in terms of prevalence of cytopenia before and after the surgery for PHPT. Correlation analysis did not reveal any significant differences between studied parameters except that there was a moderate-weak relation between PTH level and neutrophile/lymphocyte rate. Mean RDW was high in patients with PHPT before the surgery, however it did not improve after the operation significantly. There are no studies in the literature evaluating RDW, MPV values and neutrophile/lymphocyte rates that are related to primary hyperparathyroidism (or secondary, tertiary hyperparathyroidism). Our study has the feature of being the first study in this field, more significant data is expected to be obtained as the number of included patients increase.