ECE2015 Eposter Presentations Calcium and Vitamin D metabolism (96 abstracts)
Effect of supplementation with vitamin D and calcium to excessive suppression of bone metabolism during antiresorptive therapy
Tijana Icin 1 , Branka Kovacev-Zavisic 1 , Jovanka Novakovic-Paro 1 , Ivana Bajkin 1 , Bojan Vukovic 2 , Ivanka Percic 2 , Nemanja Kovacev 3 & Milica Medic-Stojanoska 1
1Clinic of Endocrinology, Diabetes and Metabolic Diseases, Medical Faculty, Clinical Center of Vojvodina, University of Novi Sad, Novi Sad, Serbia; 2Medical Faculty, Emergency Center, Clinical Center of Vojvodina, University of Novi Sad, Novi Sad, Serbia; 3Clinic of Orthopaedic Surgery and Traumatology, Clinical Center of Vojvodina, Novi Sad, Serbia.
Introduction: Long-term therapy with bisphosphonates is considered a risk factor for the development of atypical fractures of the femur. One of the mechanisms of these fractures is excessive suppression of bone metabolism. The supplementation dose of vitamin D and calcium could have an impact on the degree of suppression of bone turnover.
The aim: To determine whether the presence or dose of supplementation with vitamin D and calcium during antiresorptive therapy have an impact on the achieved degree of suppression of bone metabolism.
Methods and materials: This was a prospective longitudinal study that included 200 postmenopausal women with antiresorptive treatment of osteoporosis. We analysed osteocalcin, CTx and ionic calcium, before treatment and 3 months after starting the therapy, and dose of supplementation with vitamin D and calcium. Based on the values of osteocalcin and CTx after 3 months of therapy, patients were divided into four groups: Group1-accelerated bone metabolism, Group2-awaited response to therapy, Group3-excessive suppression of bone resorption, Group4-excessive suppression of bone remodelling.
Results: Calcium supplementation was carried out in 77.5% of patients, usually in a dose of 500 mg/day and vitamin D in 92.5% usually at a dose of 400 IU. The dose of calcium is satisfied recommended dose in 14% of cases, a dose of vitamin D in 42.5% of cases. Calcium supplementation was not associated with the degree of suppression of bone metabolism (P=0.557, χ=0.155). Supplementation with vitamin D was not associated with the degree of suppression of bone metabolism (P=0.652, χ=0.241). The values of ionic calcium before and during treatment were in the reference range.
Conclusion: Most patients with antiresorptive therapy for osteoporosis takes supplementation with vitamin D and calcium. The supplementation dose in many cases was less than the recommended dose. The degree of suppression of bone metabolism during antiresorptive therapy did not depend on the supplementation dose of calcium nor vitamin D.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more