Endocrine Abstracts

Background: Hashimoto’s thyroiditis is the most common autoimmune endocrine disorders and often leads to hypothyroidism. There is a relation with Vitamin D levels, vitamin D receptor (VDR) and HT reported. More than 30 gene polymorphisms are found in VDR gene. The most common four types of polymorphisms studied in autoimmune disease are FokI (exon 2), BsmI (intron 8), ApaI (intron 8) and TaqI (exon 9). The aim of this study is to investigate the association between VDR FokI gene polymorphism and Hashimoto’s thyroiditis subtypes.

Methods: We performed a case-control study that included 139 cases with HT (50 euthyroid, 50 subclinical hypothyroid, 39 overt hypothyroid patients) and 50 healthy control. Subjects were collected from Endocrinology Clinic. VDR gene polymorphisms FokI were typed by RFLP.

Results: At the FokI genotype distribution analysis, 49% of FF genotype, 36.7% of Ff genotype and 14.3% of ff genotype were detected in euthyroid Hashimoto’s thyroiditis group. The FF genotype in 46.9%, Ff genotype in 38.8% and ff genotype in 14.3% of group were detected in subclinical hypothyroidism group. In evident hypothyroidism, the FF genotype was observed in 36.8%, Ff genotype in 52.6% and ff genotype in 10.5% of the patient. In the control group, FF genotype in 58%, Ff genotype in 32% and FF genotype in 10% of the group were determined. At the FokI genotype distribution in euthyroid, subclinical hypothyroid and control groups the FF genotype was observed in the highest rate while Ff genotype was detected at the highest rate in evident hypothyroidism group. There were no statistically significant differences were observed in all Hashimoto’s thyroiditis group compared with the control group. No statistically significant difference was seen between euthyroid, subclinical hypothyroid, evident hypothyroid groups and the control group.

Conclusion: This study showed that VDR FokI gene polymorphism not affected the occurrence of the HT.

Disclosure: Grant numbers 2012 TPF6