ECE2015 Eposter Presentations Reproduction, endocrine disruptors and signalling (92 abstracts)
Clinical characteristics of different phenotypes of polycystic ovary syndrome
Tamara Bogavac 1 , Djuro Macut 1 , Ivana Bozic Antic 1 , Jelica Bjekic-Macut 2 , Danijela Vojnovic Milutinovic 3 , Bojana Popovic 1 , Biljana Kastratovic-kotlica 4 , Dusan Ilic 1 , Tatjana Isailovic 1 , Valentina Elezovic 1 , Sanja Ognjanovic 1 & Svetozar Damjanovic 1
1Clinic of Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia; 2CHC Bezanijska kosa, Belgrade, Serbia; 3IBISS, University of Belgrade, Belgrade, Serbia; 4Clinic of Gynecology and Obstetrics, Belgrade, Serbia.
Introduction: Although phenotype D is well recognised in clinical studies about PCOS, there is still a debate if this phenotype should be evaluated as part of PCOS spectrum. The aim of this study was to evaluate usual anthropometric characteristics in PCOS phenotypes.
Methodology: We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (Controls: 25.41±5.16 kg/m2; 30.35±5.62 years). PCOS group was divided into four phenotypes: a (anovulation (ANOV), hyperandrogenism (HA), polycystic ovary morphology (PCOM)), B (ANOV, HA), C (HA, PCOM) and D (ANOV, PCOM) and analyzed for menarche age, number of menstrual cycles/year, mean diameter of the ovaries measured by the ultrasound, and degree of hirsutism assessed by Ferriman–Gallway score.
Results: Phenotype C had the same mean number of menstrual cycles per year as Controls (11.39±1.18 vs 11.74±0.96, P>0.05) and significantly more than all other phenotypes (A: 5.62±3.49, B: 7.24±4.27, D: 6.82±3.39, P<0.05). Menarche started significantly (P<0.05) later in phenotype A and D (12.94±1.69 and 13.09±1.12 years, respectively) in comparison to phenotypes B, C and Controls (12.51±1.26, 12.59±1.40 and 12.52±1.36 years, respectively). Ovaries were significantly smaller (P<0.05) in phenotype B and Controls (28.79±7.09 and 27.93±5.73 mm, respectively, P>0.05) than phenotypes A (33.13±5.29 mm), C (31.94±4.76 mm) and D (32.76±3.89 mm). Degree of hirsutism was the same in phenotype D and Controls (3.24±2.50 and 3.73±2.23, P>0.05) and was significantly (P<0.001) lower than in all other phenotypes (A: 9.99±6.13, B: 10.33±4.73 and C: 11.64±5.66, P>0.05).
Conclusion: Our results showed that assessed clinical characteristics (menstrual frequency and degree of hirsutism) are in relation to the mainly hyperandrogenic phenotypes while it was not a case for the ovarian characteristics.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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