Endocrine Abstracts

Background: Few previous studies suggested a negative impact of obesity on anti-Mullerian hormone (AMH) serum levels in patients with decreased ovarian reserve, but the data regarding the relationship between AMH and adiposity in the same category of patients without severe excess of body weight are scarce.

Aim: The aim of the study was to evaluate the relationship between AMH serum levels and BMI in normal weight and overweight patients with reduced ovarian reserve.

Material and methods: Patients were 196 infertile women with reduced ovarian reserve defined as AMH≤1 ng/ml evaluated in a Department of Assisted Reproduction between January 2007 and January 2014. Inclusion criterion was BMI≤30 kg/m². Weight, height, age were recorded and AMH was measured in all the patients.

Results: Mean age of the study group was 36.9±4 years and mean BMI 21.8±2.8 kg/m² (170 normal weight patients and 26 overweight patients). Serum AMH was negatively correlated with age (r=−0.154, P<0.05) and BMI (r=−0.147, P<0.05) when the entire group was analyzed, but the correlation was lost when only normal weight women were included in analysis. In a multivariate linear regression model both age (P<0.0001) and BMI (P=0.017) were independently associated with serum AMH.

Conclusion: We found that in women with decreased ovarian reserve there is a negative impact of only slightly increased adiposity on serum AMH and this effect is independent of age.