Endocrine Abstracts

Background: PCOS and thyroid disorder are two of the most frequent endocrine disorder in the general population. Although, the aetiopathogenesis of thyroiditis and PCOS is completely different this two entities have many features in common (cystic ovaries in hypothyroidism and thyroid disorder in PCOS).

Objective: Our objective was to assess the increased incidence of thyroid disorder in females with PCOS.

Methods and materials: We conduct a prospective study from 2005 to 2012, 150 PCOS and 80 controls were enrolled. All patients were screened for TSH, TPO antibodies, and a clinical exam of the neck.

Results: PCOS and controls were matched for age and BMI. The mean BMI was 27.2 kg/m² and the mean age 24.5 years. The thyroid disorders were more frequent in PCOS (8.66%) than in controls (1.25%). two goitres, nine thyroiditis, and two infraclinical hypothyroidism (TSH >4.5 UI/ml) were found in PCOS women. The TPO antibodies were positive in 6% of them and the mean level=250 UI/ml.

Discussion: In our study thyroid disorders are more frequent in PCOS women than in controls, however the prevalence (8.66%) is quite similar to the general population. Increased BMI, insulin resistance, hyperostrogenemia, proinflammatory markers are thought to be the link between this two disorders.

Conclusion: There is enough literature report to argue that prevalence thyroid disorders is increased in PCOS women. The link between this two disorders is not elucidated.