Endocrine Abstracts

Patients with insulin resistance are often confronted with conception difficulties. Our database of 1178 conceivable female patients with metabolic disorder shows that more than 40% of them suffer from menstrual cycle disorders. More than 25% out of 480 pregnant women with hyperinsulinaemia had at least one assisted reproduction procedure in their lives. 42% of patients with insulin resistance experienced missed abortion, out of them 26% one time, 12% two times. Our aim was to provide a complex and tailored treatment to women with insulin mediated metabolic disorder who desired pregnancy. The tailored treatment consisted of diet, physical exercises based on BMI and body constitution, medical treatment (if needed) and coaching. Setting BMI goals between 20 and 24, the outstanding role of dietary treatment is remarkable: patients attending (not necessarily following!) dietary counselling became pregnant up to 90%, while patients not attending these consultations were successful up to 68%. Owing to this complex and tailored method more than 71% out of 224 women became pregnant. Pregnancy rates were different according to ages: 75% up to 35 years of age, getting less to 43% above 40 years of age. During pregnancy the complex tailored treatment continued. GDM occurred in 39%of the cases. Mothers with former PCOS developed GDM up to 36%. The average birth weight of the babies was 3321 g. The complex tailored treatment requires a close follow-up and interactive cooperation.