ECE2015 Eposter Presentations Reproduction, endocrine disruptors and signalling (92 abstracts)
A possible link between LH and macrophage migration inhibitory factor levels in polycystic ovary syndrome
Mehmet Calan 1 , Tuncay Kume 2 , OzgUr Yilmaz 3 , Tugba Arkan 1 , Gokcen Unal Kocabas 4 , Ozge Dokuzlar 5 , Kemal Aygun 5 , Mehmet Asi Oktan 5 , Nilay Danıs 5 & Muzaffer Temur 3
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Dokuz Eylul University Medical School, Izmir, Turkey; 2Department of Medical Biochemistry, Dokuz Eylul University Medical School, Izmir, Turkey; 3Department of Obstetrics and Gynecology, Manisa Merkezefendi Hospital, Manisa, Turkey; 4Division of Endocrinology and Metabolism, Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey; 5Department of Internal Medicine, Dokuz Eylul University Medical School, Izmir, Turkey.
Purpose: Macrophage migration inhibitory factor (MIF) is a multi-functional cytokine which plays a role in metabolic and inflammatory processes. Increasing evidence suggests that there is a link between MIF and ovulation. We aimed to evaluate plasma MIF levels in women with polycystic ovary syndrome (PCOS) and to determine whether MIF levels differ between the follicular phase and mid-cycle of the menstrual cycle in eumenorrheic women.
Methods: Ninety women with PCOS and 80 age- and BMI-matched healthy eumenorrheic women were consecutively recruited into this prospective observational study. For all subjects, plasma MIF levels in early follicular phase were measured by ELISA; for the 40 healthy controls, MIF levels were also measured during mid-cycle of the same menstrual cycle.
Results: Plasma MIF levels were significantly higher in women with PCOS than in eumenorrheic women (14.16±1.59 ng/ml vs 10.39±0.70 ng/ml; P<0.001). MIF levels were significantly higher at mid-cycle than in the follicular phase in eumenorrheic women (11.15±0.61 ng/ml vs 10.56±0.82 ng/ml; P<0.001). MIF was positively correlated with BMI, hs-CRP, and HOMA-IR in both groups. MIF was positively correlated with LH and free-testosterone only in the PCOS group. Binary logistic regression analyses revealed that the odds ratio (OR) for PCOS independently increases linearly with elevated MIF (OR=1.385, 95% CI=1.087–1.764, P=0.017).
Conclusion: MIF may play a crucial role in the reproductive system in women, including the development of PCOS and normal ovulation.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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