ECE2015 Eposter Presentations Reproduction, endocrine disruptors and signalling (92 abstracts)
Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome
Muzaffer Temur 1 , Özgür Yilmaz 1 , Saliha Aksun 2 , Pelin Özün Özbay 3 , Mehmet Calan 4 , Tuncay Küme 5 , Murat Karakulak 6 & Hüseyin Anil Korkmaz 7
1Department of Obstetrics and Gynecology, Manisa Merkezefendi State Hospital, Manisa, Turkey; 2Department of Medical Biochemistry, Izmir Katipcelebi University Medical School, Izmir, Turkey; 3Department of Obstetrics and Gynecology, Aydin Obstetrics and Pediatrics Hospital, Aydin, Turkey; 4Department of Endocrinology, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey; 5Department of Medical Biochemistry, Dokuz Eylul University Medical School, Izmir, Turkey; 6Department of Obstetrics and Gynecology, Silivri State Hospital, Istanbul, Turkey; 7Division of Pediatric Endocrinology, Dr Behçet Uz Children Research and Training Hospital, Izmir, Turkey.
Purpose: This study aims to compare serum urocortin-3 levels in women with PCOS and healthy women, and establish what role urocortin-3 levels play in PCOS.
Methods: Fifty-two patients with PCOS and 55 healthy women were included in the study, matched for age and BMI. Fasting blood glucose (FBG), insulin, hs-CRP, urocortin-3, and free testosterone levels of the all participants were measured. HOMA-IR was used to calculate the insulin resistance.
Results: Circulating urocortin-3 levels were significantly increased in women with PCOS than in control subjects (54.49±5.77 pmol/l vs 51.28±5.86 pmol/l, P=0.005). Urocortin-3 levels positively correlated with hs-CRP in PCOS group (r=0.391, P=0.004). There was no any correlation between urocortin-3 and other parameters. Multivariable binary logistic regression analysis showed that elevated urocortin-3 levels were associated with PCOS. Receiver operating characteristic curve analysis showed that urocortin-3 levels were useful as a diagnostic marker for PCOS. The optimal cut-off value of urocortin-3 for detecting PCOS was ≥51.46 pmol/l, at which the sensitivity was 75% and specificity was 68%.
Conclusions: Circulating concentration of urocortin-3 are significantly increased in women with PCOS. Furthermore, increased urocortin-3 levels were associated with PCOS after adjustment for potential confounders. This link in between urocortin-3 and PCOS may be due to an underlying chronic inflammation in subjects with PCOS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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