Propylthiouracil-induced hepatotoxicity in Graves

Hela Marmouch; Sondes Arfa; Tesnim Slim; Fadia Boubaker; Hanene Sayadi; Manel Jmal; Ines Khochtali

doi:10.1530/endoabs.37.EP1287

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Endocrine Abstracts (2015) 37 EP1287 | DOI: 10.1530/endoabs.37.EP1287

ECE2015 Eposter Presentations Clinical Cases–Thyroid/Other (101 abstracts)

Propylthiouracil-induced hepatotoxicity in Graves' disease: a case report

Hela Marmouch ^1, , Sondes Arfa ¹ , Tesnim Slim ¹ , Fadia Boubaker ¹ , Hanene Sayadi ^1, , Manel Jmal ^1, & Ines Khochtali ^1,

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¹Department of Internal Medicine–Endocrinology, Monastir, Tunisia; ²Faculty of Medicine, Monastir, Tunisia.

Introduction: Propylthiouracil-induced severe hepatotoxicity is a relatively rare occurrence, with very few cases reported in the literature. The management of this complication in pregnancy can be a challenge because of the effects of the various treatment options on the foetus.

Case presentation: We report a case of hyperthyroidism in a 28-year-old woman that occurred at 20 weeks gestation. This situation was due to Graves’ disease. Propylthiouracil treatment was used. The following of the pregnancy doesn’t shows any side effects. 15 days after delivery, she has a vomiting and fatigue. Check list show elevated ALAT=1000 UI/l. This liver toxicity has been managed by stopping this medication. After 4 days, ALAT romain to normal rate.

Conclusion: This case illustrates a rare complication of treatment with a presumed safe drug during pregnancy followed by adverse maternal outcomes due to the hepatotoxicity treatment.