Endocrine Abstracts

Reports of pregnancy in acromegalic women are uncommon.

Case 1: Patient K., 25-year-old., 01/04/2008 – transsphenoidal adenomectomy in connection with active acromegaly (GH/OGTT – 47.2–64.0–38.0–29.6–28.7 ng/ml; macroadenoma 19×14×12 mm with compression of optic chiasm). Postoperative remission of the disease, recovery of menstrual function without additional therapy. At the end of August 2008 the patient became pregnant, in the beginning of June 2009 – childbirth. After 6 months – the second successful pregnancy. The both children are wellbeing till now.

Case 2: Patient Yas.,32-year-old., 24/02/2005 – partial transsphenoidal adenomectomy without remission due to spreading macroadenoma into left cavernous sinus around ICA. After surgery patient received additional therapy with SSA (Somatulin 30 mg twice a week till 2006, then Sandostatin LAR 40 mg in combination with cabergoline 1 mg a week) without cure of the disease: IGF1 is not low then 770 ng/ml (62–280). 03/04/08 – radiotherapy (‘Novalis’), 22 G. After 1 year – spontaneous pregnancy. Due to severe headache in view of active disease patient independently continued therapy with Sandostatin LAR 40 mg during all period of pregnancy. In the beginning of March 2010 – childbirth. The boy is wellbeing till now.

Case 3: Patient P., 30-year-old. Primary infertility during 10 years. Two-fold partial transsphenoidal adenomectomy (in 1998 and 2001) without remission due to macroadenoma with supra-infra-latero-cellar extension. In 2002 – conventional gamma-therapy, 50 G. In one year after radiotherapy – active acromegaly (GH-25 ng/ml, IGF1 – 690 ng/ml) and spontaneous pregnancy with successful outcome. The boy is wellbeing till now. After childbirth SSA therapy have been initiated.