ECE2015 Eposter Presentations Endocrine tumours (69 abstracts)
Evaluation of metabolic syndrome in patients with primary hyperparathyroidism
Mustafa Caliskan 1 , Muyesser Sayki Arslan 1 , Esra Tutal 1 , Selvihan Beysel 1 , Melia Karakose 1 , Mahmut Apaydin 1 , Ozgur Ozcelik 1 , Muhammed Kizilgul 1 , Nujen Colak Bozkurt 1 , Erman Cakal 1 , Mustafa Ozbek 1 & Tuncay Delibasi 1,
1Department of Endocrinology and Metabolism, Diskapi Teaching and Research Hospital, Ankara, Turkey; 2Hacettepe University, School of Medicine (Kastamonu), Ankara, Turkey.
Aims: Primary hyperparathyroidism (PH) has been reported to be associated with increased insulin resistance, hypertension, dyslipidemia and cardiovascular inflammatory markers. The aims of this study were to evaluate the rate of metabolic syndrome (MS) and effect of parathormone, calcium and phosphorus levels to MS components in PH subjects.
Methods: One hundred and fifty one subjects, 23 men and 128 women, aged 53±11.2 years with newly diagnosed PH were recruited from our outpatient clinic. All subjects underwent measurements of height, weight, waist and hip. Metabolic variables were obtained after an overnight fasting. MS was diagnosed using the Adult Treatment Panel III criteria (ATP III).
Results: The rate of the MS (76/151, 50.3%) was higher to that reported in the general Turkish population (36.6%). 15.2% (n=23) of patients had diabetes mellitus and 72.8% (n=110) of patients had hypertension. Serum levels of glucose and triglyceride were 95.2±17.1 and 152.1±73 mg/dl, respectively. The rate of obesity, overweight was 52.3 and 35.7% respectively. There were no significant differences between the levels of calcium, phosphorus and parathormone levels (11.16±0.8 vs 11.01±0.6 mg/dl, 2.59±0.45 vs 2.63±0.48 mg/dl, 259.6±238 vs 247.5±276 mg/dl respectively) according to MS presence (Table 1).
| Age | 53±11.2 |
| Sex (M/F) | 23 M/128 F |
| Glucose (mg/dl) | 95.2±17.1 |
| Triglyceride (mg/dl) | 152.1±73 |
| Calcium (mg/dl) | 11.9±0.67 |
| Phosphorus (mg/dl) | 2.6±0.47 |
| Parathormone (mg/dl) | 253.6±256.9 |
| Metabolic syndrome (%) | 50.3 |
| Diabetes mellitus (%) | 15.2 |
| Hypertension (%) | 72.8 |
| Obesity (%) | 52.3 |
| Overweight (%) | 35.7 |
Conclusion: Based on the results of this study, the rate of the MS in PH was found to be higher than that reported in the general Turkish population. Metabolic control must be considered in the clinical management of patients diagnosed PH.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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