ECE2015 Eposter Presentations Steroids, development and paediatric endocrinology (36 abstracts)
Paediatric hypothyroidism: effect of thyroxin replacement therapy on growth hormone secretion and linear growth velocity
Sadia Saqib 1 , Amjad Rashid Kiani 1 , Urooj Anwar 1 , Maleeha Akram 1 , Gulbin Shahid 2 , Osama Ishtiaq 3 , Afzaal Ahmad 1 , Mazhar Qayyum 1 & Shakeel Raza Rizvi 1
1Department of Zoology Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi, Pakistan; 2The Children’s Hospital Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan; 3Shifa International Hospital, Islamabad, Pakistan.
Thyroid gland secretes thyroid hormones, which play a critical role in growth, differentiation, reproduction and metabolism, whereas hypothyroidism in children is associated with short stature and normalisation of thyroid function with thyroxin replacement therapy increases linear growth velocity (LGV). In stimulating LGV, thyroxin may have its direct effects on bone cells or it may affect LGV through its effect on growth hormone (GH) secretion. The present study attempted to examine the effect of thyroxin replacement therapy on LGV in hypothyroid short children, its effect on GH secretion and the stage of puberty at which thyroxin replacement therapy could be more effective in influencing LGV. Blood samples were obtained and plasma T3, T4, TSH, GH and IGF-I were determined using specific assay systems. Data were analysed using Student’s t-test and ANOVA. Twenty hypothyroid children (ten boys and ten girls) diagnosed on the basis of lower plasma levels of T4 and T3 and higher plasma concentrations of TSH, were given varying doses of thyroxin (16.6–150 μg/day for 12–36 months) administered orally at different ages (8–16 years) and stages (early, mid and late) of pubertal development. Following replacement therapy, children grew at a greater rate at higher doses of thyroxin. In addition, thyroxin replacement at early puberty in girls and at mid puberty in boys caused higher increases in LGV. The concentrations of GH and IGF-I increased significantly after treatment of hypothyroid patients with thyroxin. In conclusion, the present study demonstrates that hypothyroid children grow at a greater rate at higher doses of thyroxin and that thyroxin replacement therapy at early puberty in girls and mid puberty in boys causes higher increases in LGV. In addition, the current investigation indicates that increases in LGV following thyroxin replacement therapy are secondary to GH and subsequent IGF-I secretion.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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