ECE2015 Eposter Presentations Thyroid (non-cancer) (160 abstracts)
Amyloid goitre as the first manifestation of systemic amyloidosis
Ibtissem Oueslati , Hana Ben Hadj Hassen , Ibtissem Ben Nacef , Nadia Mchirgui , Karima Khiari & Néjib Ben Abdallah
Department of Endocrinology, Charles Nicolle University Hospital, Tunis, Tunisia.
Introduction: Thyroid gland may be asymptomatically involved in most patients with secondary systemic amyloidosis. However, clinically detectable amyloid goiter is quite rare; often it is seen in patient with kidney involvement. We report one case of amyloid goitre without kidney manifestation.
Case report: A 30-year-old male diagnosed with bilateral bronchiectasis since 1992 was admitted with rapidly growing goiter associated with dysphagia for solids, change in voice, weight loss and dyspnea. The goitre was nodular large and hard. The rest of the examination was normal. His thyroid function tests were normal, antithyroglobulin and antimicrosomial antibodies were negatives. As he had signs of compression, total thyroidectomy was performed without complication. Histological exam showed type AA amyloid throughout the gland. Labial biopsy was positive for type AA amyloid. Evolution was favorable and 2 years later proteinuria was still negative.
Conclusion: We report perhaps, a new case of amyloid goitre without renal manifestation in the course of secondary amyloidosis. A preoperative diagnosis of amyloid goiter must be considered in patients with thyromegaly who have a predisposing risk factor for developing amyloidosis.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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