ECE2015 Eposter Presentations Thyroid (non-cancer) (160 abstracts)
Paraoxonase and arylesterase levels in autoimmune thyroid diseases
Hakan Korkmaz 1 , Suzan Tabur 1 , Mesut Özkaya 1 , Elif Oguz 2 , Nurten Aksoy 3 & Ersin Akarsu 1
1Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Gaziantep University, Gaziantep, Turkey; 2Faculty of Medicine, Department of Pharmacology, Harran University, Sanliurfa, Turkey; 3Faculty of Medicine, Department of Clinical Biochemistry, Harran University, Sanliurfa, Turkey.
Objective: The aim of this study was to evaluate paraoxonase-1 (PON1) activities and its association with oxidative stress status in autoimmune thyroid disease (AITD).
Materials and methods: Patients with 25 Hashimoto thyroiditis (HT) and 25 Graves’ disease (GD) and 27 healthy controls were enrolled in the study. Blood samples were obtained in euthyroid period and 3 months after the initiation of medical treatment. Serum samples from AIT diseases and healthy control group were analysed for paraoxanose (PON), arylesterase (ARE) activities, lipid hydroperoxide (LOOH) and total free sulfhydryl (–SH) levels.
Results: The preoperative PON and –SH levels of the patients with AIT were significantly lower compared to those of the control group (P<0.001, for each), while LOOH levels were significantly higher (P<0.001, for each). There was no significant difference between the patients with AIT and the healthy control groups in terms of ARE levels (P>0.05). PON levels showed a positive correlation with –SH (r=0.522, P<0.001) and a negative correlation with LOOH (r=−0.487, P<0.001).
Conclusion: Serum PON levels is decrease in patients with AIT, and serum PON is positively correlated with –SH, a well known antioxidant, and negatively correlated with LOOH, an oxidant.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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