Prevalence of thyroid dysfunction in Spain: diabetes study

Sergio Valdes; Cristina Maldonado-Araque; Maria Jose Tapia; Ana Lago; Vidal Perez-Valero; Albert Goday; Luis Castano; Edelmiro Delgado; Joan Vendrell; Gemma Rojo-Martinez; Federico Soriguer

doi:10.1530/endoabs.37.EP1002

EP1002

Prev Next

Section Contents Cite

Endocrine Abstracts (2015) 37 EP1002 | DOI: 10.1530/endoabs.37.EP1002

ECE2015 Eposter Presentations Thyroid (non-cancer) (160 abstracts)

Prevalence of thyroid dysfunction in Spain: diabetes study

Sergio Valdés ¹ , Cristina Maldonado-Araque ¹ , María José Tapia ¹ , Ana Lago ¹ , Vidal Perez-Valero ¹ , Albert Goday ² , Luis Castaño ³ , Edelmiro Delgado ⁴ , Joan Vendrell ⁵ , Gemma Rojo-Martínez ¹ & Federico Soriguer ¹

Err

Author affiliations View ePoster Download ePoster

¹Hospital Regional de Málaga, Málaga, Spain; ²Hospital del Mar, Barcelona, Spain; ³Hospital de Cruces, Baracaldo, Spain; ⁴Hospital Central de Asturias, Oviedo, Spain; ⁵Hospital Universitario Joan XXIII, Tarragona, Spain.

Introduction: Thyroid dysfunction is a common health problem. Its prevalence may vary in different populations, and in Spain, it has not been sufficiently studied. The aim of this study was to evaluate the prevalence of thyroid dysfunction (clinical and subclinical) in our country.

Materials and methods: The diabetes study is a national, cross-sectional, population-based survey. Target population: the entire Spanish population >18 years. Sample: >5000 subjects in 112 clusters. Participation: 57%. Variables: clinical, demographic, and lifestyle survey, physical examination and blood sampling. Study period: 2008–2010. Specific variables for this study: the concentration of TSH, FT₄, FT₃, and TPOab antibodies was determined by chemiluminescence (Roche) in 4530 subjects. Iodine concentration was measured in an isolated urine sample by the Benotti technique.

Results: The prevalence of treated hypothyroidism, untreated subclinical hypothyroidism and untreated clinical hypothyroidism were 4.2% (95% CI 3.6–4.9%), 4.6% (95% CI 4.0–5.2%), and 0.3% (95% CI 0.1–0.5%) respectively. The prevalence of hyperthyroidism was 0.8% (95% CI 0.6–1.1%) and the prevalence of positive thyroid autoimmunity (TPO >50 IU/ml) and 7.5% (95% CI 6.7–8.3%). All thyroid disorders were more prevalent in women than in men: hypothyroidism (total) 13.3% (12.0–14.6%) vs 4.8% (3.8–5.7%), hyperthyroidism 1.1% (0.7–1.4%) vs 0.6% (0.3–1.0%), and positive thyroid autoimmunity 10.8% (9.6–12.1%) vs 4.1% (3.2–5.0%) respectively. Hypothyroidism was associated with the presence of positive anti-TPO antibodies (P<0.001) and elevated urinary iodine levels (P<0.001).

Conclusions: We report for the first time the prevalence of thyroid dysfunction in a representative sample of the Spanish population.

Disclosure: CIBERDEM, Ministry of Health, Spanish Society of Diabetes. FIS PI11/02755. SAEN.