Endocrine Abstracts

Introduction: Vitamin D plays an essential role in calcium homeostasis and bone metabolism, immune modulation, and control of other hormonal systems. Vitamin D deficiency is also common for many reasons. On the other hand, thyroid diseases have widespread systemic manifestations including their effect on bone metabolism.

Aim: To assess vitamin D status among Egyptian patients with different thyroid states: euthyroid, hypothyroid, or hyperthyroid states.

Subjects and method: 45 participants (39 females and six males) were divided into three groups: Group 1: (15) euthyroid subject, group 2: (15) hyperthyroid subjects, and group 3: (15) hypothyroid subjects. Diseases and drugs that affect vitamin D were excluded. History taking including dietary habits, sun exposure and clothes and full examination was done. Serum 25-hydroxy vitamin D level by ELISA, ionised calcium, phosphorus, alkaline phosphatase, TSH, free T₃, and free T₄ were assessed.

Results: The study showed high incidence of vitamin D deficiency among all groups. 21 subjects (45.6%) had vitamin D deficiency (<30 nmol/l), 24 subjects (52.1%) had insufficiency (30–75 nmol/l), and one subject (2.7%) had vitamin D sufficiency. 25-hydroxy vitamin D was significantly different between groups with the level of 25±15.78 nmol/l in group 1, 42.88±20.03 nmol/l in group 2, and 28.46±20.03 nmol/l (P<0.05). 60% in group 1, 50% in group 2, and 33.3% in group 3 had sufficient sun exposure with no significant difference between the three groups (P=0.8). Nearly 80% were veiled with no significant difference between the three groups (P=0.2). No difference between groups as regard sufficient dietary vitamin D (P>0.05). There was no significant difference between groups as regard serum ionised calcium and phosphorus and alkaline phosphatase (P>0.05).

Conclusion: Vitamin D was deficient in the different status of thyroid function. Assessment of vitamin D and replacement might be recommended in patient with thyroid disorder.