Endocrine Abstracts

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Treatment of hyperthyroidism with antithyroid drugs has recently been shown to have an effect on MMI/Carbimazole embryopathy at a specific early window in gestation. This has important implications for management.There is agreement that untreated overt gestational hypothyroidism is associated with significant adverse obstetric and fetal/neonatal effects. Although there is also substantial evidence that gestational subclinical hypothyroidism (SCH) is asso...

Thyroid hormones (T4 and T3) have a major role in brain development, and their deficits during critical stages during the fetal and neonatal periods may cause profound intellectual and neuromotor deficits. A particular example is the X-linked Allan-Herndon-Dudley syndrome, caused by mutations of the cellular transporter for thyroid hormone MCT8 (SLC16A2). In this presentation I will first review the pathophysiology of thyroid hormone transport and metabol...