Endocrine Abstracts

The relationship between subclinical hypothyroidism (SH) and cardiovascular (CV) risk is still matter of debate. While the key-role of thyroid hormones in modulation of several atherosclerotic factors is well established, the mechanisms of TSH’s action on CV system are still largely unknown.In adults with SH a pattern of CV abnormalities (dyslipidemia, insulin resistance, endothelial and diastolic dysfunction) has been observed even in mild SH cases...

The actions of thyroid hormones (TH) are mediated by receptors (TRα1, TRβ1, TRβ2), encoded by separate genes (THRA, THRB), with differing tissue distribution. TRβ2 mediates negative feedback within the hypothalamic-pituitary axis, with TRβ1 being expressed in the liver & kidney; TRα1 predominates in the myocardium and skeletal muscle.Resistance to Thyroid Hormone, usually due to heterozygous TRβ mutations (...

Thyroid hormone (TH) is one of the key players in modulating cardiovascular function. The hormone increases heart rate and force of contraction by modulating cardiac gene expression, thereby providing a molecular explanation for the clinical correlation between hyperthyroidism and cardiovascular mortality. The talk will present current aspects of cardiovascular function mediated by newly discovered TH metabolites. Recent studies have shown that a single injection of 3-iodo-<sm...