Endocrine Abstracts

The distal gut harbours microbial communities that outnumber our own eukaryotic cells. Over the last 15 years, our work has been devoted to examine the way by which gut microbiota interacts with nutrients and host physiology. We and others have suggested that cross-talks between gut microbiota and the host cells contribute to the regulation of energy, glucose and lipid homeostasis.We described the concept of metabolic endotoxemia (increase in plasma LPS ...

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In light of the ever-increasing incidences of obesity and T2DM, development of novel therapeutic or preventative measures to combat these epidemics is of utmost importance. Identification of a causal relationship between an altered maternal metabolic homeostasis and an increased propensity for the unborn child to develop metabolic disorders throughout lifetime has shifted considerable amount of attention towards understanding the underlying cellular and molecular alterations. ...